Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand.
نویسندگان
چکیده
7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulges.
منابع مشابه
Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligandw
Single-base bulges in DNA are irregularities that may arise from replication errors or from recombination between imperfectly homologous sequences. Owing to their inherent thermodynamic instability, bulges are susceptible targets for small molecules and proteins with recognition capabilities. A number of ligands have been developed that can recognize adenine (A), guanine (G), or cytosine (C) at...
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ورودعنوان ژورنال:
- Chemical communications
دوره 6 شماره
صفحات -
تاریخ انتشار 2009